Understanding how the immune system affects Candida albicans in the gut
Official title: Dissecting the impact of immune environment on Candida albicans pathogenic potential in the gut
Funded at University of Colorado Denver · NIH-10903924 · Data updated 2026-11-12
This study is looking at how your immune system affects the way a common fungus called Candida albicans behaves in your gut, especially how it can cause problems, and it's for anyone interested in understanding gut health and infections related to this fungus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $460,011 |
| NIH project number | 5DP2AI177927-02 |
| Project ID | NIH-10903924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with immune deficiencies or those experiencing gastrointestinal issues related to Candida infections.
✕Less likely to help
Patients with healthy immune systems and no history of Candida infections may not benefit from this research.
What this research studies
This research investigates how different immune environments influence the ability of Candida albicans, a common fungus in the gut, to cause disease. The study will explore the role of immune factors, particularly IgA antibodies, in regulating the behavior of Candida albicans, including its ability to form structures that can invade tissues and promote inflammation. By examining these interactions, the research aims to uncover how immune status affects the pathogenic potential of this fungus in individuals. This could lead to new insights into gut health and infections related to Candida.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating infections caused by Candida albicans in patients with compromised immune systems.
How similar studies have gone: Previous research has shown that understanding the immune interactions with gut microbiota can lead to significant advancements in treating infections, suggesting this approach has potential for success.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Ost, Kyla — University of Colorado Denver
- Study coordinator: Ost, Kyla
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.