Understanding how the immune system affects breast cancer outcomes
Official title: A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer
Funded at University of California, San Francisco · NIH-10898863 · Data updated 2026-11-12
This study is looking at how genes and the environment around tumors affect the immune response in women with high-risk breast cancer, with the hope of finding better, personalized treatment options just for you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 3, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $173,620 |
| NIH project number | 5K01CA279498-02 |
| Project ID | NIH-10898863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with high-risk breast cancer who are participating in the I-SPY 2 Trial.
✕Less likely to help
Patients with low-risk breast cancer or those not involved in the I-SPY 2 Trial may not benefit from this research.
What this research studies
This research focuses on using advanced computational and machine learning techniques to analyze data from the I-SPY 2 Trial, which involves around 2000 women with high-risk breast cancer. The goal is to uncover how genetic factors and the tumor microenvironment influence the immune response in breast cancer patients. By integrating various biological data, the research aims to enhance personalized medicine approaches for treating breast cancer. Patients may benefit from insights that could lead to more tailored and effective treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved personalized treatment options for breast cancer patients based on their unique immune responses.
How similar studies have gone: Previous research using similar computational and multi-omic approaches has shown promise in understanding cancer biology and improving treatment outcomes.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Sayaman, Rosalyn Wong — University of California, San Francisco
- Study coordinator: Sayaman, Rosalyn Wong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.