Understanding how the immune system affects Alzheimer's disease
Role of Adaptive Immunity in Etiology of Alzheimer’s Disease andAlzheimer’s Disease-Related Dementias
This study is looking at how certain immune cells in our body help get rid of harmful proteins linked to Alzheimer's disease, and it hopes to find new ways to support these immune responses to improve treatment options for people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11088840 on NIH RePORTER |
What this research studies
This research investigates the role of the adaptive immune system in clearing toxic proteins associated with Alzheimer's disease. It focuses on how specific immune cells, particularly T effector and T regulatory cells, interact with brain cells to remove harmful Aβ oligomers. By examining mitochondrial function and its impact on these immune responses, the study aims to uncover mechanisms that contribute to Alzheimer's progression and cognitive decline. Patients may benefit from insights that could lead to new therapeutic strategies targeting immune function in Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those showing early cognitive decline.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the immune system's ability to combat Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the immune system's role in neurodegenerative diseases, suggesting potential for success in this area.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wallace, Douglas C — Children's Hosp of Philadelphia
- Study coordinator: Wallace, Douglas C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.