Understanding how the immune system affects ALS based on age and sex
Creating a foundation for personalized age- and sex-based immune-targeted therapies from an ALS longitudinal cohort by identifying peripheral and central immune signatures
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11036251
This study is looking at how the immune system affects the progression of ALS and how things like age and hormones play a role, with the goal of finding personalized treatments that could help slow down the disease for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11036251 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the immune system in the progression of amyotrophic lateral sclerosis (ALS) by analyzing immune profiles in patients over time. It aims to identify how factors like age, sex, and sex hormones influence these immune profiles and their connection to neuronal damage and survival rates in ALS patients. By understanding these relationships, the research seeks to develop personalized therapies that target the immune system to slow or stop ALS progression. Patients will be monitored for changes in their immune responses, which could lead to new treatment strategies tailored to individual needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis, particularly those interested in personalized treatment approaches.
Not a fit: Patients with other neurological conditions unrelated to ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized immune-targeted therapies that significantly improve outcomes for ALS patients.
How similar studies have performed: Previous research has shown promise in targeting the immune system for ALS treatment, but this approach is particularly focused on personalized therapies based on immune profiles, making it a novel endeavor.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOUTMAN, STEPHEN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: GOUTMAN, STEPHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease