Understanding how the immune system activates after traumatic injuries
Official title: Mechanisms of Complement Activation in Traumatic Injury
Funded at University of Nebraska Medical Center · NIH-10985724 · Data updated 2026-11-12
This study is looking at how a part of your immune system called the complement system affects recovery in people who have had serious injuries, with the goal of finding ways to help them heal better and avoid complications.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $166,644 |
| NIH project number | 1K08HL171936-01A1 |
| Project ID | NIH-10985724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 1-44 who have experienced a traumatic injury requiring hospitalization.
✕Less likely to help
Patients with non-traumatic injuries or those outside the specified age range may not benefit from this research.
What this research studies
This research investigates the role of the complement system, a part of the immune response, in patients who have suffered traumatic injuries. It aims to understand how complement activation contributes to organ failure and delayed mortality in trauma patients. By studying the relationship between inflammation, coagulopathy, and complement activation, the research seeks to identify potential therapeutic targets to improve patient outcomes. The approach includes clinical assessments and laboratory assays to analyze blood samples from trauma patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce organ failure and mortality in trauma patients.
How similar studies have gone: Previous research has indicated that understanding the complement system's role in trauma could lead to significant advancements in treatment, suggesting a promising avenue for further exploration.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Barrett, Christopher David — University of Nebraska Medical Center
- Study coordinator: Barrett, Christopher David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.