Understanding how the immune environment affects cancer risk in patients with MGUS
Official title: DELINEATE THE TUMOR IMMUNE MICROENVIRONMENT FOR BETTER UNDERSTANDING IMMUNOTHERAPY RESPONSE
Funded at Baylor College of Medicine · NIH-11116722 · Data updated 2026-11-12
This study is looking at how the immune system and bone marrow environment work in people with MGUS, a condition that can sometimes lead to blood cancers, to find ways to prevent it from getting worse, and if you have MGUS, you can join in by sharing your blood samples and talking about your health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $186,712 |
| NIH project number | 3U54CA272691-02S1 |
| Project ID | NIH-11116722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with monoclonal gammopathy of undetermined significance (MGUS).
✕Less likely to help
Patients who do not have MGUS or related blood disorders may not benefit from this research.
What this research studies
This research investigates the tumor immune microenvironment in patients with monoclonal gammopathy of undetermined significance (MGUS), a precancerous condition that can lead to various blood cancers. By analyzing the immune responses and the bone marrow environment, the study aims to identify factors that contribute to the progression of MGUS to more severe conditions like multiple myeloma and chronic lymphocytic leukemia. Patients with MGUS may have their blood samples analyzed and participate in discussions about their health and potential interventions. The goal is to develop targeted strategies for cancer prevention and interception.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for patients at risk of developing blood cancers from MGUS.
How similar studies have gone: Previous research has shown promise in understanding the immune microenvironment in cancer progression, making this approach both relevant and potentially impactful.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Yong — Baylor College of Medicine
- Study coordinator: Li, Yong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.