Understanding how the HUSH complex affects HIV-1 latency
The HUSH complex in HIV-1 latency
['FUNDING_R37'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11082489
This study is looking at how certain proteins in your body help keep HIV hidden in your immune cells, which makes it hard to cure the infection, and the researchers hope to find new ways to tackle this problem.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11082489 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the HUSH complex in the latency of HIV-1, which is a significant barrier to curing HIV infection. The study aims to identify the host factors that contribute to the silencing of HIV-1 proviruses in memory CD4+ T cells, which are resistant to treatment. By using advanced techniques like genome-wide screens and targeted protein fusion methods, researchers will explore how these factors influence HIV-1 transcription and latency. The ultimate goal is to develop new strategies that could lead to effective cures for HIV-1 infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV-1 or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively eliminate HIV-1 from the body.
How similar studies have performed: Previous research has shown promise in understanding HIV latency and the mechanisms involved, but this specific approach focusing on the HUSH complex is relatively novel.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUBAN, JEREMY — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: LUBAN, JEREMY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus