Understanding how the Huntingtin protein helps repair DNA in neurons
Official title: Dissecting Key Interactions of the HTT Transcription Coupled Repair Complex
Funded at University of California-Irvine · NIH-10863628 · Data updated 2026-11-12
This study is looking at how a protein called Huntingtin helps fix DNA damage in brain cells, which could lead to new treatments for people with Huntington's Disease by understanding how different genes affect the disease's start and progression.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32NS136263-01 |
| Project ID | NIH-10863628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Huntington's Disease, particularly those with varying ages of onset and genetic backgrounds.
✕Less likely to help
Patients with other neurological disorders not related to Huntington's Disease may not receive any benefit from this research.
What this research studies
This research investigates the role of the Huntingtin protein in repairing DNA damage in neurons, particularly in the context of Huntington's Disease (HD). The study aims to identify new therapeutic targets by examining how genetic variants of DNA repair proteins influence the onset of HD. By focusing on the transcription coupled non-homologous end joining (TC-NHEJ) complex, which includes Huntingtin and other DNA repair proteins, the research seeks to uncover mechanisms that could slow disease progression and improve symptoms for patients. The approach involves detailed biochemical assays and genetic analyses to understand these interactions better.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down the progression of Huntington's Disease and improve the quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting DNA repair mechanisms in other neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Pendlebury, Devon — University of California-Irvine
- Study coordinator: Pendlebury, Devon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.