Understanding how the Huntingtin protein helps repair DNA in neurons
Dissecting Key Interactions of the HTT Transcription Coupled Repair Complex
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10863628
This study is looking at how a protein called Huntingtin helps fix DNA damage in brain cells, which could lead to new treatments for people with Huntington's Disease by understanding how different genes affect the disease's start and progression.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10863628 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Huntingtin protein in repairing DNA damage in neurons, particularly in the context of Huntington's Disease (HD). The study aims to identify new therapeutic targets by examining how genetic variants of DNA repair proteins influence the onset of HD. By focusing on the transcription coupled non-homologous end joining (TC-NHEJ) complex, which includes Huntingtin and other DNA repair proteins, the research seeks to uncover mechanisms that could slow disease progression and improve symptoms for patients. The approach involves detailed biochemical assays and genetic analyses to understand these interactions better.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's Disease, particularly those with varying ages of onset and genetic backgrounds.
Not a fit: Patients with other neurological disorders not related to Huntington's Disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down the progression of Huntington's Disease and improve the quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting DNA repair mechanisms in other neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENDLEBURY, DEVON — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: PENDLEBURY, DEVON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease