Understanding how the human proteasome and protein complexes are formed
Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes
This study is looking at how certain proteins in our cells come together and work, which could help us understand and treat health issues like cancer better, so patients can benefit from new insights into their conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10891493 on NIH RePORTER |
What this research studies
This research focuses on the molecular mechanisms that govern the assembly of the human proteasome and other protein complexes. By utilizing advanced techniques like cryogenic electron microscopy and CRISPR/Cas gene editing, the team aims to study these proteins in their natural cellular environments. This approach allows for a more accurate understanding of how these complexes function and interact, which is crucial for addressing various health conditions, including cancers. Patients may benefit from insights gained into the biological processes that underlie their diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein assembly and degradation, particularly those with cancer.
Not a fit: Patients with conditions unrelated to protein complexes or those who do not have a significant protein misfolding component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to protein misfolding and degradation, such as cancer.
How similar studies have performed: Other research has shown success using similar methodologies in understanding protein complexes, indicating a promising avenue for further exploration.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Zhao, Jianhua — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Zhao, Jianhua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.