Understanding how the human immune system responds to arenavirus infections
Genetic, structural and functional profiling of the human antibody response to arenavirus infection
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10908465
This study is looking at how our immune system fights off Lassa virus, which can make people very sick, to find new ways to create vaccines and treatments that could help patients in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10908465 on ClinicalTrials.gov |
What this research studies
This research investigates the immune response to arenavirus infections, particularly focusing on Lassa virus, which causes severe disease in humans. By utilizing advanced techniques for antibody discovery and characterization, the project aims to uncover the genetic and structural properties of antibodies that can effectively combat these viruses. The goal is to enhance our understanding of how the immune system can provide protection, which is crucial for developing effective vaccines and treatments. Patients may benefit from insights that could lead to new therapeutic options against arenavirus infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit are individuals living in regions affected by arenavirus infections, particularly those at risk of Lassa fever.
Not a fit: Patients who do not live in endemic areas or who are not at risk for arenavirus infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines and treatments for arenavirus infections, potentially saving lives.
How similar studies have performed: Previous research has shown promise in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRINEY, BRYAN — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: BRINEY, BRYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Arenaviridae Infections, Arenavirus Infections