Understanding how the human genome is structured and its impact on gene activity
Fine-Scale Genome Folding Relative to Transcription and Location
['FUNDING_OTHER'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10862640
This study is looking at how the way our genes are folded in the cell affects how they work, which could help us understand more about genetic regulation and find new ways to treat certain conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10862640 on ClinicalTrials.gov |
What this research studies
This research investigates the intricate folding of the human genome and how this structure affects gene transcription. By examining chromatin compartments and gene-loops at a high resolution, the study aims to uncover how these features change during transcription and how their spatial location within the nucleus influences their function. The research involves developing advanced software tools to analyze these genomic structures more effectively and conducting genomic investigations to explore the relationships between chromatin organization and gene activity. Patients may benefit from insights gained into genetic regulation and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or conditions related to gene expression.
Not a fit: Patients with conditions unrelated to genetic regulation or chromatin structure may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation, potentially informing new treatments for genetic disorders.
How similar studies have performed: Other research has shown promising results in understanding genome organization and its effects on gene expression, indicating that this approach has the potential for significant insights.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROWLEY, MICHAEL JORDAN — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: ROWLEY, MICHAEL JORDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.