Understanding how the human cytomegalovirus enters different types of cells
Human Cytomegalovirus Entry into Cells Mediated by Pentamer and Trimer Complexes
This study is looking at how the human cytomegalovirus (HCMV) gets into different types of cells in the body, especially those in the immune system and brain, to help find new ways to prevent and treat HCMV-related illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10898841 on NIH RePORTER |
What this research studies
This research investigates how the human cytomegalovirus (HCMV) infects various cell types, including those in the immune system and the central nervous system. The study focuses on the role of specific viral proteins, known as pentamer and trimer complexes, in facilitating the virus's entry into cells. By examining the pathways through which HCMV enters these cells, the research aims to identify potential targets for vaccines and therapies. Patients may benefit from insights that could lead to improved prevention and treatment strategies for HCMV-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include neonates, organ transplant recipients, and individuals with compromised immune systems who are at risk for HCMV infections.
Not a fit: Patients who are not at risk for HCMV infection or who have already developed immunity to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines and therapies for HCMV, reducing the risk of complications in vulnerable populations.
How similar studies have performed: Previous research has shown promise in targeting viral entry mechanisms for other viruses, suggesting that this approach could yield valuable insights for HCMV as well.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Johnson, David C. — Oregon Health & Science University
- Study coordinator: Johnson, David C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.