Understanding how the human cerebellum develops
In vitro approaches to study human cerebellar development
['FUNDING_R21'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10951406
This study is looking at how the human cerebellum develops differently from that of animals, which could help us understand cerebellar diseases better, especially by exploring how certain cells help make neurons in the brain.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10951406 on ClinicalTrials.gov |
What this research studies
This research investigates the unique features of human cerebellar development that differ from those in commonly used animal models. By using in vitro assays and live imaging techniques, the study aims to characterize specific cellular features in the human cerebellum, which is crucial for understanding cerebellar diseases. The focus is on identifying the roles of expanded progenitor zones that contribute to the formation of neurons in the cerebellum. This research could provide insights into the cellular and molecular basis of cerebellar disorders, which are often poorly understood.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cerebellar disorders or malformations.
Not a fit: Patients with conditions unrelated to cerebellar development or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cerebellar diseases.
How similar studies have performed: While there has been significant research on cerebellar development in animal models, this approach focusing on human-specific features is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HALDIPUR, PARTHIV — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: HALDIPUR, PARTHIV
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.