Understanding how the human cerebellum develops
Official title: In vitro approaches to study human cerebellar development
Funded at Seattle Children's Hospital · NIH-10951406 · Data updated 2026-11-12
This study is looking at how the human cerebellum develops differently from that of animals, which could help us understand cerebellar diseases better, especially by exploring how certain cells help make neurons in the brain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 16, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $478,732 |
| NIH project number | 1R21NS138661-01 |
| Project ID | NIH-10951406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cerebellar disorders or malformations.
✕Less likely to help
Patients with conditions unrelated to cerebellar development or function may not benefit from this research.
What this research studies
This research investigates the unique features of human cerebellar development that differ from those in commonly used animal models. By using in vitro assays and live imaging techniques, the study aims to characterize specific cellular features in the human cerebellum, which is crucial for understanding cerebellar diseases. The focus is on identifying the roles of expanded progenitor zones that contribute to the formation of neurons in the cerebellum. This research could provide insights into the cellular and molecular basis of cerebellar disorders, which are often poorly understood.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cerebellar diseases.
How similar studies have gone: While there has been significant research on cerebellar development in animal models, this approach focusing on human-specific features is relatively novel.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Haldipur, Parthiv — Seattle Children's Hospital
- Study coordinator: Haldipur, Parthiv
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.