Understanding how the human brain develops and its link to neurodevelopmental diseases.
Developmental Topology of the Human Cerebral Cortex
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10887282
This study is looking at how the human brain develops, especially in relation to conditions like autism and schizophrenia, by using special lab-grown brain models to find new ways to understand and treat these disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10887282 on ClinicalTrials.gov |
What this research studies
This research investigates the development of the human cerebral cortex and its implications for neurodevelopmental disorders like autism and schizophrenia. By studying primary brain tissue and using advanced in vitro models called cerebral organoids, the research aims to uncover unique aspects of human brain development that are not captured by traditional animal models. The focus is on specific neural progenitor cell types that contribute to the growth and complexity of the human brain, which could lead to new insights into brain evolution and potential therapies for related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those on the autism spectrum.
Not a fit: Patients with neurodevelopmental disorders not related to the cerebral cortex may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neurodevelopmental disorders and the development of targeted therapies.
How similar studies have performed: Other research has shown promise in understanding brain development through similar approaches, but this specific focus on human cortical development is relatively novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRIEGSTEIN, ARNOLD — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KRIEGSTEIN, ARNOLD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder