Understanding how the human body responds to measles vaccination
Official title: What is the human antibody response to measles virus vaccination?
Funded at La Jolla Institute for Immunology · NIH-10993615 · Data updated 2026-11-12
This study is looking at how our bodies respond to the measles vaccine by checking the antibodies we produce, which could help make vaccines better, especially for people who can't get live vaccines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $221,888 |
| NIH project number | 5R21AI180456-02 |
| Project ID | NIH-10993615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have received the measles vaccine and are willing to participate in antibody response assessments.
✕Less likely to help
Patients who have never been vaccinated against measles or those with severe immune deficiencies may not benefit from this research.
What this research studies
This research investigates the human antibody response to the measles virus vaccination, focusing on how the immune system reacts to the vaccine. By analyzing the antibodies produced, the study aims to identify which parts of the measles virus are most effective in triggering a protective immune response. This knowledge could help improve vaccine development and strategies, especially for populations that cannot receive live vaccines. The research employs advanced techniques to measure antibody responses and understand their protective mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved measles vaccination strategies and potentially new vaccine formulations that are effective for all populations.
How similar studies have gone: Previous research on antibody responses to other viral vaccines has shown success in identifying protective immune mechanisms, suggesting that this approach could yield valuable insights for measles vaccination as well.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Saphire, Erica Ollmann — La Jolla Institute for Immunology
- Study coordinator: Saphire, Erica Ollmann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.