Understanding how the human body repairs damaged DNA
Deciphering the progression and regulation of human translesion DNA synthesis
['FUNDING_OTHER'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-11088759
This study looks at how our cells can keep making DNA even when it's damaged, which is important for understanding how some cancer cells survive and resist treatment, and it could help improve cancer therapies in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-11088759 on ClinicalTrials.gov |
What this research studies
This research investigates how the human genome is replicated despite constant damage from various sources. It focuses on a process called translesion DNA synthesis (TLS), which allows cells to continue replicating DNA even when it is damaged. By studying the specialized DNA polymerases involved in TLS, the research aims to uncover how this process can lead to both cell survival and potential cancer development. The findings could help improve cancer therapies by targeting the mechanisms that allow cancer cells to resist treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by DNA damage and repair mechanisms.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not related to DNA damage and repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting the DNA repair mechanisms that allow cancer cells to survive chemotherapy.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEDGLIN, MARK — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: HEDGLIN, MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Cancer Cause, cancer cell, Cancer Etiology, Cancer Induction