Understanding how the HIV-1 latent reservoir forms
Formation of the HIV-1 Latent Reservoir
This study is looking into how and when the HIV-1 virus hides in the body, especially in people starting treatment, to help improve future treatment options for everyone living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10764793 on NIH RePORTER |
What this research studies
This research investigates the formation of the HIV-1 latent reservoir, which is a collection of cells that harbor the virus in a dormant state. It aims to redefine how this reservoir is formed, particularly focusing on the timing of its development in relation to the initiation of therapy. By analyzing different definitions of the latent reservoir and examining its formation in both men and women, the research seeks to uncover critical insights that could influence treatment strategies. The methodology includes studying viral DNA in various tissues to understand the dynamics of the reservoir.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are beginning antiretroviral therapy.
Not a fit: Patients who are not infected with HIV-1 or those who are not starting therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV-1 infection and potentially eradicating the virus from the body.
How similar studies have performed: Previous research has shown promising results in understanding HIV reservoirs, but this approach offers a novel perspective on their formation.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Swanstrom, Ronald I — Univ of North Carolina Chapel Hill
- Study coordinator: Swanstrom, Ronald I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.