Understanding how the hippocampus helps with memory in primates
Cellular mechanisms of hippocampal theta oscillations
This study is looking at how a part of the brain called the hippocampus helps us remember things, using monkeys to learn more about the brain's activity during memory processing, which could help improve treatments for memory problems like Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10668962 on NIH RePORTER |
What this research studies
This research investigates the cellular and microcircuit mechanisms of the hippocampus, a brain region crucial for memory formation. By using a non-human primate model, the study aims to explore how theta oscillations, which are important for memory processing, occur at a cellular level. Researchers will employ advanced techniques like whole-cell patch clamping and pharmacology to gain insights into the hippocampal function in primates, which could lead to better understanding and treatment of memory-related disorders such as Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or related memory impairments.
Not a fit: Patients with memory issues not related to hippocampal dysfunction or those with other neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Alzheimer's disease and other memory-related conditions.
How similar studies have performed: Previous research has shown promise in understanding hippocampal function through animal models, but this specific approach in primates is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Barria, Andres — University of Washington
- Study coordinator: Barria, Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.