Understanding how the hippocampus communicates with the supramammillary area
Official title: Inhibitory hippocampal projections to the Supramammillary area
Funded at University of Minnesota · NIH-10996324 · Data updated 2026-11-12
This study is looking at how signals from a part of the brain called the hippocampus affect another area involved in understanding social situations and space, which could help us learn more about brain function and possibly improve treatments for brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $565,552 |
| NIH project number | 1R01NS139469-01 |
| Project ID | NIH-10996324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive decline or symptoms related to Alzheimer's disease or similar neurological conditions.
✕Less likely to help
Patients with non-neurological conditions or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the connections between the hippocampus and the supramammillary area (SuM), focusing on how inhibitory signals from the hippocampus influence the SuM's role in processing social and spatial information. By examining specific populations of neurons that send inhibitory signals to the SuM, the research aims to uncover the mechanisms behind these interactions. The study will utilize advanced techniques to manipulate and observe these neuronal connections in living models, providing insights into their functions and potential implications for neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions like Alzheimer's disease and other neurological disorders.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding neuronal connectivity and its implications for neurological disorders.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Krook-Magnuson, Esther — University of Minnesota
- Study coordinator: Krook-Magnuson, Esther
Related research
Other NIH-funded projects on the same topics.
-
Investigating biological markers related to human reproduction and development
This study is looking at how different factors in our bodies affect reproduction and the health of children and teens, and it's for anyone interested in understanding more about these important topics by analyzing samples like blood and urine without changing anything in their daily lives.
-
AI-powered liver cancer screening using ultrasound blood flow patterns
A new AI-based method analyzes liver blood flow signals to help detect liver cancer early in people with liver disease, especially in settings with limited resources.
-
Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
-
Understanding how survivorship care plans affect health outcomes for cancer survivors
A study will look at whether survivorship care plans help reduce deaths and improve health for adults who have survived cancer.
-
Understanding the experience of ovarian cancer after diagnosis to improve survivorship
This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.
-
Minnesota Population Center: a hub for migration, family and community data science
A university research center helps researchers study population dynamics by sharing data, training researchers, and communicating findings to diverse audiences.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.