Understanding how the hippocampus communicates with the supramammillary area
Inhibitory hippocampal projections to the Supramammillary area
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-10996324
This study is looking at how signals from a part of the brain called the hippocampus affect another area involved in understanding social situations and space, which could help us learn more about brain function and possibly improve treatments for brain disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10996324 on ClinicalTrials.gov |
What this research studies
This research investigates the connections between the hippocampus and the supramammillary area (SuM), focusing on how inhibitory signals from the hippocampus influence the SuM's role in processing social and spatial information. By examining specific populations of neurons that send inhibitory signals to the SuM, the research aims to uncover the mechanisms behind these interactions. The study will utilize advanced techniques to manipulate and observe these neuronal connections in living models, providing insights into their functions and potential implications for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline or symptoms related to Alzheimer's disease or similar neurological conditions.
Not a fit: Patients with non-neurological conditions or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions like Alzheimer's disease and other neurological disorders.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding neuronal connectivity and its implications for neurological disorders.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KROOK-MAGNUSON, ESTHER — UNIVERSITY OF MINNESOTA
- Study coordinator: KROOK-MAGNUSON, ESTHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease