Understanding how the Hippo signaling pathway is regulated
Upstream regulation of the Hippo signaling pathway
This study is looking at a protein called Mtm that helps control how our organs grow and stay healthy, with the hope that understanding it better could lead to new ways to tackle cancer and other health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10806182 on NIH RePORTER |
What this research studies
This research investigates the Hippo signaling pathway, which plays a crucial role in controlling organ size and tissue health. The study focuses on a specific protein, Drosophila Myotubularin (Mtm), that may regulate this pathway. By examining how Mtm affects cell growth and differentiation, the researchers aim to uncover new insights into the mechanisms that could lead to cancer and other disorders. Patients may benefit from a better understanding of how disruptions in this pathway contribute to disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or conditions related to cell growth and differentiation.
Not a fit: Patients with conditions unrelated to the Hippo signaling pathway may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other disorders linked to the Hippo pathway.
How similar studies have performed: Previous research has shown that understanding signaling pathways like Hippo can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Yu, Jianzhong — University of Connecticut Storrs
- Study coordinator: Yu, Jianzhong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.