Understanding how the Hippo pathway controls growth and development
Regulation and function of the Hippo pathway in growth control
This study is looking at a system in our bodies that helps control growth and healing, which can go wrong in diseases like cancer, to find out how it works and how we might use that knowledge to create better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11002640 on NIH RePORTER |
What this research studies
This research investigates the Hippo pathway, a crucial regulator of growth, tissue regeneration, and organ size, which is often disrupted in diseases like cancer. The study focuses on the molecular mechanisms of this pathway, including key proteins and their interactions that influence cell growth and metabolism. By examining how various signals affect the Hippo pathway, the research aims to uncover new insights into its role in health and disease, potentially leading to innovative therapeutic strategies. Patients may benefit from a better understanding of how cancer develops and progresses, which could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or conditions related to dysregulation of growth and development.
Not a fit: Patients with conditions unrelated to the Hippo pathway or those not experiencing growth-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that target the Hippo pathway to control cancer growth and improve patient outcomes.
How similar studies have performed: Previous studies have shown promising results in understanding the Hippo pathway's role in cancer, indicating that this research builds on established findings.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Wang, Wenqi — University of California-Irvine
- Study coordinator: Wang, Wenqi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.