Understanding how the herpes virus replicates its DNA
Proteomics of HSV1 Replication
['FUNDING_OTHER'] · MAYO CLINIC ROCHESTER · NIH-10894745
This study is looking at how the Herpes Simplex Virus 1 (HSV1) copies itself in our cells, which could help us find new ways to treat infections caused by this virus, especially those affecting the eyes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10894745 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of DNA replication in Herpes Simplex Virus 1 (HSV1), a virus that can cause serious eye infections and other disorders. By using advanced techniques to isolate and analyze proteins involved in the replication process, the study aims to uncover how HSV1 hijacks the host's cellular machinery for its own replication. The research employs a method called iPOND-SILAC-MS, which allows for the identification of proteins associated with the replication process, providing insights into potential therapeutic targets. This could lead to better antiviral therapies for conditions caused by HSV1.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with HSV1 infections, particularly those experiencing complications such as eye infections.
Not a fit: Patients with other viral infections or those who do not have HSV1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antiviral therapies for patients suffering from HSV1-related infections.
How similar studies have performed: Previous research has shown promise in understanding viral replication mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOHNI, KAREEM N — MAYO CLINIC ROCHESTER
- Study coordinator: MOHNI, KAREEM N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.