Understanding how the herpes virus reactivates in the eye
Ocular HSV: Mechanism of virus reactivation
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11011490
This study is looking at how the herpes virus can wake up in nerve cells and cause eye problems, with the goal of finding ways to stop this from happening, which could help people with eye infections caused by the virus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11011490 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the reactivation of the herpes simplex virus (HSV) in sensory neurons, particularly focusing on its impact on eye diseases. The study aims to uncover how certain viral proteins interact with host cell receptors to trigger reactivation from a dormant state. By examining these interactions in animal models, the research seeks to identify potential strategies to prevent or limit the reactivation of the virus, which can lead to serious eye conditions. Patients may benefit from insights that could lead to new treatments for ocular herpes infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of ocular herpes infections or those at risk for herpes-related eye diseases.
Not a fit: Patients who have never experienced herpes infections or those with unrelated eye conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the reactivation of the herpes virus, reducing the risk of vision loss in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding viral reactivation mechanisms, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GHIASI, HOMAYON — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: GHIASI, HOMAYON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.