Understanding how the herpes virus assembles and spreads in nerve cells
Molecular and cellular mechanisms of HSV-1 assembly and egress
This study is looking at how the herpes simplex virus (HSV-1) moves in and out of nerve cells, which could help us understand why it sometimes causes serious brain problems, and it's for anyone interested in learning more about how this virus works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-11081982 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the herpes simplex virus type 1 (HSV-1) assembles and exits from nerve cells. It focuses on how the virus interacts with specialized neuronal cell biology, particularly during the infection and reactivation phases. The study employs advanced techniques to analyze the intracellular transport and exocytosis of the virus, aiming to uncover the viral factors that influence these processes. By understanding these mechanisms, the research hopes to provide insights into how HSV-1 can lead to severe neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with recurrent herpes simplex virus infections or those at risk of developing neurological complications from the virus.
Not a fit: Patients who do not have herpes simplex virus infections or related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for herpes virus infections and related neurological diseases.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Hogue, Ian B — Arizona State University-Tempe Campus
- Study coordinator: Hogue, Ian B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.