Understanding how the herpes virus and immune system genes affect Alzheimer's disease
Intersection of HSV-1 and microglial genetics in AD
This project explores how the immune system's response to the herpes simplex virus (HSV-1) might be influenced by our genes, potentially increasing the risk for Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11103332 on NIH RePORTER |
What this research studies
Researchers are looking into how the body's immune system, particularly its response to the common herpes simplex virus (HSV-1), might play a role in the development and progression of Alzheimer's disease. We know that certain genes linked to Alzheimer's affect the immune system, and there's growing evidence that infections could contribute to the disease. This work aims to uncover the specific ways that our genetic makeup and immune responses to HSV-1 might increase someone's risk for Alzheimer's. By combining genetic studies, human immunology, and advanced laboratory models, we hope to find new clues about this complex condition.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals with Alzheimer's disease, those at risk, or anyone interested in the underlying causes of neurodegenerative conditions.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease causes, potentially opening doors for new ways to prevent or treat it by targeting immune responses or viral infections.
How similar studies have performed: While the idea of the immune system and pathogens in Alzheimer's has gained support, this specific combination of HSV-1, microglial genetics, and Alzheimer's risk is a novel and comprehensive approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Bradshaw, Elizabeth M — Columbia University Health Sciences
- Study coordinator: Bradshaw, Elizabeth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.