Understanding how the Hedgehog pathway affects treatment responses in pediatric brain tumors.
Regulation of the Hedgehog pathway and Medulloblastoma response to radiochemotherapy
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-11054665
This study is looking at how a special signaling system in cells affects aggressive brain tumors in kids, and it aims to find new ways to make treatments like radiation and chemotherapy work better for children with medulloblastoma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11054665 on ClinicalTrials.gov |
What this research studies
This research investigates the Hedgehog (HH) signaling pathway, which is crucial for the development and function of cells, particularly in medulloblastomas, a type of aggressive brain tumor in children. The study aims to uncover how this pathway is regulated and how it interacts with other cellular processes, particularly focusing on a novel mechanism involving glucose-sensing. By using advanced techniques like mass spectrometry and specific antibodies, researchers hope to identify new ways to enhance the effectiveness of radiochemotherapy for patients with medulloblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with medulloblastoma, particularly those whose tumors show activation of the Hedgehog pathway.
Not a fit: Patients with other types of brain tumors or those whose medulloblastoma does not involve the Hedgehog pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for children with medulloblastoma, potentially increasing survival rates and reducing treatment side effects.
How similar studies have performed: Previous research has shown promising results in targeting the Hedgehog pathway in medulloblastoma, indicating that this approach has potential for success.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEI, HUADONG — GEORGETOWN UNIVERSITY
- Study coordinator: PEI, HUADONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, cancer cell, cancer therapy