Understanding how the heart's structure develops using advanced technology.
Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell Multiomics
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11074091
This study is looking at how the material surrounding heart cells affects heart development by using human stem cells to create tiny heart models, which could help us find new ways to understand and treat heart diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11074091 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the extracellular matrix (ECM) in heart development by using human stem cells to create cardiac organoids. The team will explore how different ECM compositions affect the formation and function of these organoids, employing machine learning and advanced cellular techniques. By analyzing the interactions between ECM and heart cells at a single-cell level, the research aims to uncover critical signaling pathways that could lead to better understanding and treatment of heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to abnormal heart development, particularly those from diverse ethnic backgrounds.
Not a fit: Patients with fully developed and healthy hearts may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new biomaterials or therapies that improve heart development and function.
How similar studies have performed: Other research has shown promise in using similar approaches to understand heart development and disease mechanisms, indicating potential for success in this area.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, JOSEPH C. — STANFORD UNIVERSITY
- Study coordinator: WU, JOSEPH C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.