Understanding how the heart's electrical system maintains its function and heals after injury
Genetic dissection of Cardiac Conduction System homeostasis and Repair
This study is looking at how heart cells keep a steady heartbeat and how they can repair themselves, especially focusing on a specific signaling process, to find new ways to help people with heart rhythm problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11002722 on NIH RePORTER |
What this research studies
This research investigates the cardiac conduction system (CCS), which is crucial for maintaining a regular heartbeat. It focuses on the molecular mechanisms that regulate CCS homeostasis and repair, particularly the role of Hippo signaling in heart cells. By studying these processes at a single-cell level, the research aims to uncover new therapeutic targets that could improve treatment for patients with heart rhythm disorders. The findings could lead to better understanding and management of arrhythmias, a common and serious heart condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with cardiac arrhythmias or those at risk of developing such conditions.
Not a fit: Patients with arrhythmias caused by non-genetic factors or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from heart rhythm disorders, potentially reducing morbidity and mortality associated with arrhythmias.
How similar studies have performed: Other research has shown promising results in understanding cardiac signaling pathways, suggesting that this approach could yield significant insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Jun — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Wang, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.