Understanding how the gut's immune system responds to inflammation
Gut Intrinsic Inflammatory Responses
This study looks at how the immune system in your gut can change from being calm to becoming inflamed, and it aims to help us understand how this affects conditions like chronic gut inflammation, which could lead to better treatments for you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11078853 on NIH RePORTER |
What this research studies
This research investigates the immune responses in the gastrointestinal tract, focusing on how the gut can switch from a state of tolerance to one of inflammation. The study examines the role of specific immune cells and cytokines in this process, particularly how inhibiting certain pathways can lead to increased inflammatory responses. By exploring these mechanisms, the research aims to provide insights into the gut's ability to respond to infections and maintain balance in the presence of various antigens. Patients may benefit from a better understanding of chronic inflammatory diseases related to gut health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic inflammatory conditions of the gastrointestinal tract, such as inflammatory bowel disease.
Not a fit: Patients with acute gastrointestinal infections or those without any inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing chronic inflammatory diseases affecting the gastrointestinal tract.
How similar studies have performed: Other research has shown promising results in understanding immune responses in the gut, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Newberry, Rodney D — Washington University
- Study coordinator: Newberry, Rodney D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.