Understanding how the gut senses mechanical changes
Mechanotransduction in gastrointestinal physiology
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10905782
This study is looking at how the gut feels pressure and how problems with this process might lead to issues like irritable bowel syndrome (IBS), so if you have IBS, this research could help you understand your symptoms better and explore new treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10905782 on ClinicalTrials.gov |
What this research studies
This research investigates how the gastrointestinal (GI) tract senses mechanical forces and how disruptions in this process can lead to conditions like irritable bowel syndrome (IBS). The study focuses on specialized cells in the gut called enteroendocrine cells (EECs) that respond to mechanical stimuli and release signaling molecules affecting gut function. By using advanced mouse models, researchers aim to uncover the cellular mechanisms behind these sensations and their implications for gut health. Patients may gain insights into the biological basis of their symptoms and potential new treatment avenues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from gastrointestinal disorders, particularly those with symptoms related to gut-brain interaction.
Not a fit: Patients with gastrointestinal conditions unrelated to mechanosensation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gastrointestinal disorders like IBS, enhancing patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding mechanosensation in other contexts, suggesting potential for success in this area as well.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEYDER, ARTHUR — MAYO CLINIC ROCHESTER
- Study coordinator: BEYDER, ARTHUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.