Understanding how the gut protects itself from inflammation caused by TNF
Official title: Novel mechanisms protecting the gut from TNF
Funded at Weill Medical Coll of Cornell Univ · NIH-11249770 · Data updated 2026-11-12
This study is looking at how certain immune cells in your gut help protect against damage and inflammation caused by a protein called TNF, which is important for people with inflammatory bowel disease (IBD), to find new ways to help manage gut health.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 18, 2023 |
| Project end | June 13, 2025 |
| Funding year | 2025 |
| Award (this year) | $69,910 |
| NIH project number | 3R37AI174468-02S1 |
| Project ID | NIH-11249770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease or those experiencing chronic gut inflammation.
✕Less likely to help
Patients with non-inflammatory gastrointestinal conditions may not receive any benefit from this research.
What this research studies
This research investigates how the gut can defend itself against damage and inflammation caused by a protein called TNF. It focuses on a specific type of immune cell, known as group 3 innate lymphoid cells (ILC3s), which play a crucial role in maintaining gut health. The researchers aim to uncover the mechanisms by which these cells produce protective substances that help balance the effects of TNF, especially in conditions like inflammatory bowel disease (IBD). By understanding these processes, the research hopes to identify new therapeutic strategies for patients suffering from chronic gut inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect the gut from inflammation and improve outcomes for patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown promise in understanding immune responses in the gut, but this specific approach focusing on ILC3s and their protective mechanisms is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Sonnenberg, Gregory F — Weill Medical Coll of Cornell Univ
- Study coordinator: Sonnenberg, Gregory F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.