Understanding how the gut protects itself from inflammation caused by TNF
Novel mechanisms protecting the gut from TNF
This study is looking at how a special type of immune cell helps keep your gut healthy and protects it from damage caused by inflammation, which is important for people with conditions like inflammatory bowel disease (IBD).
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10890196 on NIH RePORTER |
What this research studies
This research investigates the role of a specific type of immune cell, known as group 3 innate lymphoid cells (ILC3s), in protecting the intestinal lining from damage caused by tumor necrosis factor (TNF), a substance that can lead to chronic inflammation. The study aims to uncover the mechanisms by which ILC3s help maintain gut health and prevent inflammation, particularly in conditions like inflammatory bowel disease (IBD). By exploring how these cells produce protective substances, the research seeks to identify new therapeutic targets for improving gut health in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel disease or related gastrointestinal conditions characterized by chronic inflammation.
Not a fit: Patients with non-inflammatory gastrointestinal disorders or those without any gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect the gut from inflammation and improve outcomes for patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding immune cell functions in the gut, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Sonnenberg, Gregory F — Weill Medical Coll of Cornell Univ
- Study coordinator: Sonnenberg, Gregory F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.