Understanding how the gut protects itself from inflammation caused by TNF
Official title: Novel mechanisms protecting the gut from TNF
Funded at Weill Medical Coll of Cornell Univ · NIH-10890196 · Data updated 2026-11-12
This study is looking at how a special type of immune cell helps keep your gut healthy and protects it from damage caused by inflammation, which is important for people with conditions like inflammatory bowel disease (IBD).
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 18, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $651,105 |
| NIH project number | 5R37AI174468-02 |
| Project ID | NIH-10890196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory bowel disease or related gastrointestinal conditions characterized by chronic inflammation.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders or those without any gastrointestinal issues may not benefit from this research.
What this research studies
This research investigates the role of a specific type of immune cell, known as group 3 innate lymphoid cells (ILC3s), in protecting the intestinal lining from damage caused by tumor necrosis factor (TNF), a substance that can lead to chronic inflammation. The study aims to uncover the mechanisms by which ILC3s help maintain gut health and prevent inflammation, particularly in conditions like inflammatory bowel disease (IBD). By exploring how these cells produce protective substances, the research seeks to identify new therapeutic targets for improving gut health in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect the gut from inflammation and improve outcomes for patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown promising results in understanding immune cell functions in the gut, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Sonnenberg, Gregory F — Weill Medical Coll of Cornell Univ
- Study coordinator: Sonnenberg, Gregory F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.