Understanding how the gut heals after injury
Official title: Coordinated matricellular regulation of intestinal injury repair and regeneration
Funded at University of Illinois at Chicago · NIH-11041136 · Data updated 2026-11-12
This study is looking at how a protein called CCN1 helps the gut heal after injury, which could be really helpful for people with conditions like inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | March 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $376,750 |
| NIH project number | 5R01DK137797-02 |
| Project ID | NIH-11041136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions that impair gut healing, such as inflammatory bowel disease or those recovering from intestinal injuries.
✕Less likely to help
Patients with stable, non-injured intestines or those without any gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the intestinal lining repairs itself after injury, focusing on the role of a protein called CCN1. It examines how CCN1 interacts with specific receptors on intestinal stem cells to promote their growth and differentiation into various cell types necessary for gut health. By studying mice models, the research aims to uncover how disruptions in these processes can lead to conditions like inflammatory bowel disease. The findings could provide insights into enhancing gut regeneration and healing.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut healing and regeneration for patients with intestinal injuries or diseases.
How similar studies have gone: Previous research has shown promising results in understanding gut regeneration mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Jun, Joon-Il — University of Illinois at Chicago
- Study coordinator: Jun, Joon-Il
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.