Understanding how the gut heals after damage
Defining post-transcriptional regulons in intestinal epithelial regeneration
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10820461
This study is looking at how the gut heals after being hurt by things like radiation or inflammation, especially for people undergoing treatments like chemotherapy, to find better ways to help it recover and stay healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10820461 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that help the intestinal lining recover from damage caused by factors like radiation, inflammation, and toxins. It focuses on post-transcriptional regulons, which are groups of mRNAs regulated by proteins that respond quickly to cellular damage. By studying these processes, the research aims to identify new strategies to enhance the healing of the gut, particularly for patients affected by treatments like chemotherapy. The findings could lead to improved therapies that support intestinal regeneration and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have experienced gastrointestinal damage due to radiation or chemotherapy.
Not a fit: Patients with intact gastrointestinal function and no history of damage from radiation or chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for patients suffering from gastrointestinal damage, improving their recovery and quality of life.
How similar studies have performed: Other research has shown promising results in understanding the role of autophagy in tissue regeneration, suggesting that this approach could yield significant insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAMILTON, KATHRYN ELIZABETH — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: HAMILTON, KATHRYN ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.