Understanding how the Golgi apparatus manages cell membrane traffic
Deciphering the logic circuit for Golgi membrane traffic
This study is looking at how a part of our cells called the Golgi apparatus helps move and process proteins, using yeast to see how it works and changes over time, which could help us learn more about how cells function and what goes wrong in certain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11012286 on NIH RePORTER |
What this research studies
This research investigates the Golgi apparatus, a crucial organelle involved in the transport and processing of proteins within cells. By studying budding yeast, the researchers aim to uncover how the Golgi organizes its membrane traffic pathways and how these pathways change as the Golgi matures. The project employs advanced imaging techniques to visualize these processes in real-time, providing insights into the dynamic nature of cellular organization. This work could enhance our understanding of cellular functions and diseases related to membrane trafficking.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions linked to cellular transport and processing, such as certain genetic disorders or metabolic diseases.
Not a fit: Patients with conditions unrelated to cellular membrane trafficking or those not affected by Golgi apparatus dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular processes that may inform treatments for diseases related to membrane trafficking dysfunction.
How similar studies have performed: While the specific approach of this research is novel, studies on membrane trafficking in yeast have previously yielded significant insights into cellular processes.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Glick, Benjamin S — University of Chicago
- Study coordinator: Glick, Benjamin S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.