Understanding how the fungus Histoplasma capsulatum grows inside human cells
Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10795858
This study looks at how the fungus Histoplasma capsulatum lives and grows inside our immune cells, focusing on what it takes from these cells to thrive, which could help us understand how it interacts with our immune system.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10795858 on ClinicalTrials.gov |
What this research studies
This research investigates how the fungal pathogen Histoplasma capsulatum survives and proliferates within human immune cells, specifically macrophages. By examining the nutrients that Histoplasma extracts from these cells, the study aims to identify the specific host molecules that support its growth. The approach combines molecular biology, genetics, and metabolomics to analyze how Histoplasma metabolizes these nutrients to meet its energy needs. This research could lead to a better understanding of the interactions between the fungus and the host immune system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are immunocompromised or have been diagnosed with histoplasmosis.
Not a fit: Patients who do not have a history of fungal infections or are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating infections caused by Histoplasma capsulatum.
How similar studies have performed: Other research has shown success in understanding fungal pathogens' interactions with host cells, making this approach promising.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAPPLEYE, CHAD A — OHIO STATE UNIVERSITY
- Study coordinator: RAPPLEYE, CHAD A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disorder