Understanding how the fungal pathogen Histoplasma becomes more harmful over time
The evolution of virulence in the fungal pathogen Histoplasma
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11020964
This study is looking at how certain genes in the Histoplasma fungus make it more likely to cause serious lung infections, and it's for anyone interested in understanding how this fungus has changed over the years and affects people's health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11020964 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that contribute to the virulence of the Histoplasma fungus, which can cause severe lung infections. By analyzing different species of Histoplasma, the researchers aim to identify specific genes that enhance the fungus's ability to cause disease. The study will involve creating genetic reference panels and testing the effects of these genes in laboratory settings. Additionally, the research will track changes in these virulence-related genes in clinical samples over the past 40 years to understand how they spread in the population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with or are at risk for infections caused by Histoplasma.
Not a fit: Patients who do not have a history of exposure to Histoplasma or related lung infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for lung infections caused by Histoplasma.
How similar studies have performed: Previous research has shown promising results in understanding fungal pathogens, indicating that this approach could yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATUTE, DANIEL — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: MATUTE, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: burden of disease