Understanding how the Fmr1 gene affects social behavior in autism
Characterization of the role of Fmr1 in oxytocin neuronal subtypes
This study is looking at how changes in a specific gene might affect social skills in people with autism, with the goal of finding new ways to help improve social interactions and behaviors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10745690 on NIH RePORTER |
What this research studies
This research investigates the specific functions of the Fmr1 gene in oxytocin neurons and how its loss contributes to social impairments in autism spectrum disorder (ASD). The study aims to uncover the mechanisms behind social reward learning and identify critical periods for therapeutic interventions. By exploring the cellular and circuit-level consequences of Fmr1 deletion, the research seeks to develop targeted approaches that could improve social behaviors in affected individuals. Patients may benefit from insights that could lead to new treatment strategies for ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, particularly those with social impairments related to the Fmr1 gene.
Not a fit: Patients without autism spectrum disorder or those whose social impairments are not linked to the Fmr1 gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance social functioning in individuals with autism.
How similar studies have performed: Previous research has shown promising results in understanding the role of genes in autism, making this approach both relevant and potentially impactful.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Dolen, Gul — Johns Hopkins University
- Study coordinator: Dolen, Gul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.