Understanding how the extracellular matrix affects organ formation
Official title: Apical extracellular matrix during organ formation
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-11113066 · Data updated 2026-11-12
This study is looking at how a special layer of proteins helps shape important organs like kidneys and lungs, using tiny creatures as models, to better understand conditions like polycystic kidney disease and lung development issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $147,087 |
| NIH project number | 1R03DE034704-01 |
| Project ID | NIH-11113066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital organ formation disorders, such as polycystic kidney disease or underdeveloped lungs.
✕Less likely to help
Patients with fully developed organs and no history of organ formation disorders may not benefit from this research.
What this research studies
This research investigates the role of the apical extracellular matrix (aECM) in the development of three-dimensional tubular organs, such as kidneys and lungs. By studying model organisms like C. elegans and Drosophila, the research aims to uncover how the aECM contributes to the proper size and shape of these organs. The project focuses on identifying key enzymes that regulate the aECM and how their modifications can impact organ formation. This could lead to insights into conditions like polycystic kidney disease and pulmonary agenesis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating organ formation disorders.
How similar studies have gone: Previous studies have shown success in understanding the role of extracellular matrices in organ development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Chung, Seyeon — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Chung, Seyeon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.