Understanding how the extracellular matrix affects early pregnancy success
Official title: Extracellular Matrix-Mediated Endometrial Decidualization and Angiogenesis
Funded at University of Vermont & St Agric College · NIH-11088174 · Data updated 2026-11-12
This study is looking at how certain changes in the tissue that supports early pregnancy might affect women who have trouble during this time, with the hope of finding ways to help those who experience early pregnancy loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $440,918 |
| NIH project number | 5R01HD111479-03 |
| Project ID | NIH-11088174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have experienced early pregnancy complications or are at risk for adverse pregnancy outcomes.
✕Less likely to help
Patients who are not pregnant or those who have no history of early pregnancy complications may not benefit from this research.
What this research studies
This research investigates the role of the extracellular matrix in the processes that support early pregnancy, particularly focusing on decidualization and angiogenesis. By studying how the remodeling of fibrillar collagen impacts the endometrium, the research aims to uncover mechanisms that contribute to early pregnancy loss. Using a novel mouse model, the team will explore how defects in these processes can lead to complications such as intrauterine hemorrhage and embryo resorption. The findings could provide insights into improving outcomes for women experiencing early pregnancy complications.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing early pregnancy loss and improving outcomes for women in their first trimester.
How similar studies have gone: Previous research has shown promising results in understanding the role of the extracellular matrix in pregnancy, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Nallasamy, Shanmugasundaram — University of Vermont & St Agric College
- Study coordinator: Nallasamy, Shanmugasundaram
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.