Understanding how the exocrine pancreas works in Type 1 Diabetes
Official title: Measuring Exocrine Pancreas Metabolism in Type 1 Diabetes
Funded at University of Florida · NIH-11063090 · Data updated 2026-11-12
This study is looking at how the pancreas works in people with Type 1 Diabetes to see if changes in its metabolism might play a role in the disease, using special mice to help understand these processes better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | May 15, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $43,138 |
| NIH project number | 5F31DK138741-02 |
| Project ID | NIH-11063090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Type 1 Diabetes, particularly those experiencing complications related to pancreatic function.
✕Less likely to help
Patients without Type 1 Diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research investigates the metabolic changes in the exocrine pancreas of individuals with Type 1 Diabetes (T1D), focusing on how these changes may contribute to the disease. The study will use a transgenic mouse model to analyze the metabolism of carbon and lipids in the exocrine pancreas, employing advanced techniques like nuclear magnetic resonance (NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS). By examining these metabolic pathways, the research aims to uncover the role of the exocrine pancreas in T1D and how it may affect overall health and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of T1D and potentially new therapeutic strategies targeting the exocrine pancreas.
How similar studies have gone: While research on the islets of Langerhans in T1D is extensive, the focus on exocrine pancreas metabolism is relatively novel and has not been widely tested.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Rushin, Anna — University of Florida
- Study coordinator: Rushin, Anna
Related research
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.