Understanding how the Epstein-Barr virus switches from dormant to active
Regulation of the Epstein-Barr Virus Lytic Switch
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10886518
This study is looking at how the Epstein-Barr virus (EBV) switches from being inactive to active, which is important for its ability to cause illnesses like certain cancers and infectious mononucleosis, and it aims to find new ways to help patients by understanding what controls this switch.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10886518 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control the Epstein-Barr virus (EBV) lytic switch, which is crucial for the virus's ability to replicate and spread. Using advanced techniques like CRISPR/Cas9, the study aims to identify host factors that influence this switch, focusing on the role of the MYC transcription factor and its interactions with the viral genome. By understanding these processes, researchers hope to uncover new insights into how EBV contributes to various diseases, including cancers and infectious mononucleosis. Patients may benefit from this research through improved understanding and potential new treatments for EBV-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are infected with Epstein-Barr virus or are at risk for EBV-related conditions.
Not a fit: Patients who are not infected with Epstein-Barr virus or do not have related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating EBV-related diseases, including certain cancers.
How similar studies have performed: Other research has shown promising results in understanding viral lytic switches, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GEWURZ, BENJAMIN ELISON — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: GEWURZ, BENJAMIN ELISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.