Understanding how the epithelial barrier functions in oral diseases
Regulation of epithelial barrier
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-11098756
This study is looking at how certain factors, like pressure and bacteria, affect the protective layer in your mouth, which is important for preventing gum diseases like periodontitis and peri-implantitis, and the findings could help improve how we manage or prevent these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11098756 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate the epithelial barrier in oral diseases like periodontitis and peri-implantitis. By using both in vivo and in vitro models, researchers will explore how factors such as mechanical pressure and bacterial signals affect the integrity of the epithelial barrier. The study focuses on key proteins like FOXO1, E-cadherin, and β-catenin, which play crucial roles in maintaining this barrier. Patients may benefit from insights gained about how to better manage or prevent these oral diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with periodontitis or peri-implantitis.
Not a fit: Patients without any oral diseases or conditions affecting the epithelial barrier may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from periodontitis and peri-implantitis.
How similar studies have performed: Previous research has shown promising results in understanding epithelial barrier functions, but this specific approach is relatively novel.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALIMPERTI, STELLA — GEORGETOWN UNIVERSITY
- Study coordinator: ALIMPERTI, STELLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.