Understanding how the epigenome controls gene expression
Nanopore based profiling of epigenetic state
This study is exploring a new way to look at how our genes are controlled in the body, using cutting-edge technology to understand how proteins interact with DNA, which could help us find better ways to diagnose and treat diseases related to gene regulation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10861728 on NIH RePORTER |
What this research studies
This research focuses on developing a new method to analyze the epigenome, which is crucial for understanding how genes are regulated in the body. By using advanced nanopore sequencing technology, the study aims to examine protein-DNA interactions and other aspects of the epigenome simultaneously. This approach will allow researchers to gain insights into gene regulation mechanisms that could be linked to various human diseases. Patients may benefit from the findings as they could lead to new diagnostic tools or treatments based on epigenetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene regulation, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to epigenetic changes or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding gene regulation and its implications for treating diseases.
How similar studies have performed: Other research has shown promise in using advanced sequencing technologies to explore epigenetic mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Timp, Winston George — Johns Hopkins University
- Study coordinator: Timp, Winston George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.