Understanding how the epigenome changes in cells during development and differentiation
Capturing the dynamic epigenome using single molecule and single cell approaches
This study is looking at how tiny changes in our cells' DNA packaging can affect how genes work, especially in the context of cancer, to help us understand more about the disease and potentially improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-10895445 on NIH RePORTER |
What this research studies
This research investigates the dynamic changes in the epigenome, specifically focusing on histone modifications that are crucial for maintaining cellular identity during development. By using advanced single molecule and single cell techniques, the researchers aim to understand how these modifications influence gene expression and contribute to genome stability. The study will explore how proteins that modify histones interact with DNA and how these interactions affect cellular functions, particularly in the context of cancer. Patients may benefit from insights gained about the mechanisms underlying cancer and other diseases related to epigenetic changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or genetic conditions linked to epigenetic changes and genome instability.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms or those not experiencing genome instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with epigenetic abnormalities.
How similar studies have performed: Other research has shown promising results in understanding epigenetic mechanisms, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Ragunathan, Kaushik — Brandeis University
- Study coordinator: Ragunathan, Kaushik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.