Understanding how the environment around pancreatic cancer tumors affects their growth
Stromal and vascular inputs into pancreatic cancer tumor neighborhoods
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10886118
This study is looking at how the environment around pancreatic cancer tumors, including blood vessels and certain supportive cells, affects the growth of the cancer, with the goal of finding new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10886118 on ClinicalTrials.gov |
What this research studies
This research investigates the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC), focusing on how the surrounding blood vessels and cancer-associated fibroblasts influence tumor growth and survival. By analyzing human datasets and mouse models, the researchers aim to identify specific characteristics of the TME that could be targeted for therapy. The study explores the relationship between tumor vascularity and the effectiveness of angiogenesis inhibitors, as well as the dependency of tumor cells on lipids from neighboring cells for survival in low-nutrient conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma, particularly those with specific tumor characteristics that may respond to targeted therapies.
Not a fit: Patients with other types of cancer or those whose pancreatic tumors do not exhibit the characteristics being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown that targeting components of the tumor microenvironment can be beneficial, but this specific approach to pancreatic cancer is innovative and not yet widely tested.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STANGER, BEN Z — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: STANGER, BEN Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.