Understanding how the environment around glioblastoma tumors affects their growth and treatment resistance
Elucidating the Role of Perivascular Niche in Glioblastoma Invasion and Therapeutic Resistance at Single Cell Resolution using Biomimetic Tumor Microenvironment Models
This study is looking at how the area around blood vessels in glioblastoma tumors helps certain stubborn cancer cells survive treatment, with the hope of finding better ways to help patients with this type of brain cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10893963 on NIH RePORTER |
What this research studies
This research investigates the role of the perivascular niche, the area surrounding blood vessels in glioblastoma tumors, in supporting glioma stem cells that resist treatment. By using advanced 3D tumor models, the study aims to explore how different cell types within this niche interact and influence tumor behavior, including growth and response to therapies. The goal is to gain insights into the mechanisms that allow these resistant cells to thrive and evade conventional treatments, ultimately improving therapeutic strategies for glioblastoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those with recurrent tumors or those who have not responded well to standard treatments.
Not a fit: Patients with non-glioblastoma brain tumors or those who are not currently undergoing treatment for glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma by targeting the mechanisms that allow tumor cells to resist therapy.
How similar studies have performed: Previous research has shown that targeting the tumor microenvironment can improve treatment outcomes in various cancers, suggesting that this approach may also be promising for glioblastoma.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Nikkhah, Mehdi — Arizona State University-Tempe Campus
- Study coordinator: Nikkhah, Mehdi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.