Understanding how the environment around blood stem cells affects leukemia growth
Targeting Microenvironmental Signals in Myeloid Malignancies
This study is looking at how the environment around blood stem cells affects the growth of acute myeloid leukemia (AML) and aims to find new ways to improve treatment for patients like you by understanding why some leukemia cells resist therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10883578 on NIH RePORTER |
What this research studies
This research investigates how the microenvironment surrounding blood stem cells influences the development and progression of acute myeloid leukemia (AML) and related conditions. By examining the interactions between leukemia cells and their niche, the study aims to uncover mechanisms that contribute to the persistence of therapy-resistant leukemia stem cells. The approach includes identifying specific signals and cell surface markers that may play a role in supporting leukemia growth, which could lead to new therapeutic strategies. Patients may benefit from insights that could improve treatment outcomes and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia or related myeloid malignancies.
Not a fit: Patients with non-myeloid malignancies or those who do not have leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the supportive environment of leukemia cells, potentially improving survival rates for patients with AML.
How similar studies have performed: Previous research has shown promising results in targeting microenvironmental factors in cancer, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Bajaj, Jeevisha — University of Rochester
- Study coordinator: Bajaj, Jeevisha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.