Understanding how the environment around blood stem cells affects leukemia
Targeting Microenvironmental Signals in Myeloid Malignancies
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11072133
This study is looking at how blood stem cells interact with their surroundings in people with acute myeloid leukemia and blast crisis chronic myeloid leukemia, to find new ways to help improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11072133 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between blood stem cells and their surrounding environment, particularly in the context of acute myeloid leukemia (AML) and blast crisis chronic myeloid leukemia (bcCML). The study aims to uncover how signals from the microenvironment influence the growth and resistance of leukemia stem cells, which are responsible for the persistence of the disease. By examining the role of specific cell interactions and surface markers, the research seeks to identify potential therapeutic targets that could improve treatment outcomes for patients with these types of leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or blast crisis chronic myeloid leukemia.
Not a fit: Patients with other types of leukemia or those who do not have myeloid malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that target the microenvironment of leukemia, potentially improving survival rates for patients.
How similar studies have performed: While the role of the microenvironment in leukemia is an emerging field, previous studies have shown promising results in targeting microenvironmental interactions in other cancers, suggesting potential for success in this area as well.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAJAJ, JEEVISHA — UNIVERSITY OF ROCHESTER
- Study coordinator: BAJAJ, JEEVISHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.