Understanding how the environment affects the growth of intestinal organoids from stem cells
4D controllable extracellular matrix properties to guide iPSC-derived intestinal organoid fate and form
['FUNDING_OTHER'] · SYRACUSE UNIVERSITY · NIH-11059999
This study is looking at how the supportive structure around cells, called the extracellular matrix, can help grow tiny models of the intestine from stem cells, which could lead to better ways to understand and treat intestinal diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SYRACUSE UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-11059999 on ClinicalTrials.gov |
What this research studies
This research investigates how the properties of the extracellular matrix (ECM) influence the development of intestinal organoids derived from induced pluripotent stem cells (iPSCs). By creating biomaterials that mimic the natural environment of the intestine, the study aims to better understand how these materials can affect cell behavior and organoid maturation. The approach involves manipulating the ECM properties to observe their impact on organoid growth and function, which could lead to more accurate models for studying human intestinal diseases. Patients may benefit from advancements in organoid technology that could improve disease modeling and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may have conditions related to intestinal health or diseases.
Not a fit: Patients with conditions unrelated to intestinal health or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective models for studying intestinal diseases, ultimately improving treatment options for patients.
How similar studies have performed: Previous research has shown promise in using organoids for modeling diseases, indicating that this approach could yield significant advancements.
Where this research is happening
SYRACUSE, UNITED STATES
- SYRACUSE UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLATCHLEY, MICHAEL — SYRACUSE UNIVERSITY
- Study coordinator: BLATCHLEY, MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.