Understanding how the environment affects the growth of intestinal organoids from stem cells
Official title: 4D controllable extracellular matrix properties to guide iPSC-derived intestinal organoid fate and form
Funded at Syracuse University · NIH-11059999 · Data updated 2026-11-12
This study is looking at how the supportive structure around cells, called the extracellular matrix, can help grow tiny models of the intestine from stem cells, which could lead to better ways to understand and treat intestinal diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00DK135907-03 |
| Project ID | NIH-11059999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who may have conditions related to intestinal health or diseases.
✕Less likely to help
Patients with conditions unrelated to intestinal health or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how the properties of the extracellular matrix (ECM) influence the development of intestinal organoids derived from induced pluripotent stem cells (iPSCs). By creating biomaterials that mimic the natural environment of the intestine, the study aims to better understand how these materials can affect cell behavior and organoid maturation. The approach involves manipulating the ECM properties to observe their impact on organoid growth and function, which could lead to more accurate models for studying human intestinal diseases. Patients may benefit from advancements in organoid technology that could improve disease modeling and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective models for studying intestinal diseases, ultimately improving treatment options for patients.
How similar studies have gone: Previous research has shown promise in using organoids for modeling diseases, indicating that this approach could yield significant advancements.
Where this research is happening
-
Syracuse University
Syracuse, United States Active
Researchers
- Principal investigator: Blatchley, Michael — Syracuse University
- Study coordinator: Blatchley, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.